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KMID : 0379520080240010011
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한국독성학회지
2008 Volume.24 No. 1 p.11 ~ p.15
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Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
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Lee Hyeung-Sik
Cho Hyung-Rae
Yang Kun-Ju
Moon Seung-Bae
Park Bok-Ryeon
Shin Hyun-Dong
Jang Hee-Jeong
Kim Lin-Su
Ku Sae-Kwang
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Abstract
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In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that Polycan™ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of Polycan™ tested in this study because the polychromatic erythrocyte ratio was detected as ＞ 0.47 in all tested groups.
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KEYWORD
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Polycan™, β-Glucan, Micronucleus test, Genotoxicity, Mice
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